![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prolactin Receptor antibody [B6.2], prediluted (ab74608) image](#ab74608ihc.jpg)
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Products:Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Receptor Tyrosine Kinases
Overview
Product name
Anti-Prolactin Receptor antibody [B6.2], prediluted
See all Prolactin Receptor products (10) ...
Description
Mouse monoclonal [B6.2] to Prolactin Receptor, prediluted
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Semi-purified human prolactin receptor.
Positive control
Human breast carcinoma tissue.
Properties
Form
Prediluted
Storage instructions
Store at +4°C.
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
ab74608 was purified from ascites
Clonality
Monoclonal
Clone number
B6.2
Isotype
IgG1
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prolactin Receptor antibody [B6.2], prediluted (ab74608)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prolactin Receptor antibody [B6.2], prediluted (ab74608) image](/ps/datasheet/Images/74/ab74608/ab74608ihc.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab74608 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
IHC-P
Application notes
IHC-P: Ready to use.
Staining of formalin/paraffin tissues requires digestion of tissue sections with pepsin at 1mg/ml Tris-HCl, pH 2.0 for 15 min at RT or 10 min at 37C.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Tissue specificity
Expressed in breast, placenta, kidney, liver and pancreas.
Sequence similarities
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Contains 2 fibronectin type-III domains.
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Cellular localization
Secreted and Membrane.
Target information above from: UniProt accessionP16471
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AI987712 antibody
- CLONE SPM213 antibody
- CPRLP antibody
see all
Database links
- Entrez Gene: 5618 Human
- Omim: 176761 Human
- SwissProt: P16471 Human
- SwissProt: Q96P35 Human
- SwissProt: Q96P36 Human
- Unigene: 368587 Human
Anti-Prolactin Receptor antibody [B6.2], prediluted images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prolactin Receptor antibody [B6.2], prediluted (ab74608)
Prolactin receptor at 1ug/ml in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue using peroxidase-conjugate and AEC chromogen. Note cell membrane and cytoplasmic staining of tumor cells.
References for Anti-Prolactin Receptor antibody [B6.2], prediluted (ab74608)
ab74608 has not yet been referenced specifically in any publications.
Publishing research using ab74608? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"