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Products:Immunology >> Innate Immunity >> Complement >> Regulatory
Overview
Product name
Anti-Properdin antibody [10C5]
See all Properdin products (6) ...
Description
Mouse monoclonal [10C5] to Properdin
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Full length native protein (purified) (Human).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
10C5
Myeloma
x63-Ag8.653
Isotype
IgG1
Light chain type
kappa
Research areas
Immunology >> Innate Immunity >> Complement >> Regulatory
Applications
Show applications key
Our Abpromise guarantee covers the use of ab17780 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
WB
Application notes
ELISA: 1/10000.
WB: Use at an assay dependent dilution. Predicted molecular weights: 25, 56 (reduced) and 220 kDa (unreduced).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Involvement in disease
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
Sequence similarities
Contains 6 TSP type-1 domains.
Cellular localization
Secreted.
Target information above from: UniProt accessionP27918
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
Database links
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
References for Anti-Properdin antibody [10C5] (ab17780)
ab17780 has not yet been referenced specifically in any publications.
Publishing research using ab17780? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"