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| Product Name | Properdin antibody [039-04] |
| | See all Properdin antibodies (4)... |
| Product type | Primary antibodies |
| Description | Mouse monoclonal [039-04] to Properdin |
| Immunogen | Full length native protein (purified) (Human). |
| Reacts with
(species key) | Hu |
| Tested applications
(see key) | ELISA, WB |
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| Abreviews | |
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| Application notes
(see key) | Recommended dilutions
ELISA: 1/10000.
WB: Use at an assay dependent dilution. Predicted molecular weights: 25, 56 (reduced) and 220 kDa (unreduced).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user. |
| Cellular localization | Secreted |
| Research areas | Immunology >> Innate Immunity >> Complement >> Regulatory |
| Relevance | This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3 and C5 convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
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| Database links | The links below go to external sites and will open in a new browser window |
| Raised in | Mouse |
| Clonality | Monoclonal |
| Clone number | 039-04 |
| Myeloma | x63-Ag8.653 |
| Isotype | IgG1 |
| Light chain type | kappa |
| Purity | Protein G purified |
| Storage buffer | Preservative: 15mM Sodium Azide
Constituents: 0.5M Sodium chloride, 0.01M Phosphate. pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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| Form | Liquid |
| Concentration | 1.000 mg/ml |
| Storage instructions | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
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| Search PubMed (MEDLINE) for references to Properdin |
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