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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-Properdin antibody [10-18]
See all Properdin products (6) ...
Description
Mouse monoclonal [10-18] to Properdin
Tested applications
ELISA, IHC-Fr, Functional Studiesmore details
Cross reactivity
Reacts with
Human
Immunogen
Native purified Properdin from human serum.
Positive control
Histology positive control tissue: Kidney from post streptococcal glomerulonephritis patients.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: Borate buffered saline, pH 8.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
10-18
Isotype
IgG1
Research areas
Immunology >> Innate Immunity >> Complement >> Regulatory
Immunology >> Innate Immunity >> Complement >> Alternative Pathway
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58984 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
IHC-Fr
Functional Studies
Application notes
ELISA: Use at an assay dependent dilution.
FuncS: Use at an assay dependent dilution.
Note: This antibody inhibits the function of Properdin. Removal of sodium azide is recommended prior to use in functional assays
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Involvement in disease
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
Sequence similarities
Contains 6 TSP type-1 domains.
Cellular localization
Secreted.
Target information above from: UniProt accessionP27918
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
Database links
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
References for Anti-Properdin antibody [10-18] (ab58984)
ab58984 has not yet been referenced specifically in any publications.
Publishing research using ab58984? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"