Anti-Properdin/PFC antibody [10-18] (ab58984)
Key features and details
- Mouse monoclonal [10-18] to Properdin/PFC
- Suitable for: ELISA, IHC-Fr, Functional Studies
- Reacts with: Human
- Isotype: IgG1
Overview
-
Product name
Anti-Properdin/PFC antibody [10-18]
See all Properdin/PFC primary antibodies -
Description
Mouse monoclonal [10-18] to Properdin/PFC -
Host species
Mouse -
Tested applications
Suitable for: ELISA, IHC-Fr, Functional Studiesmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length native protein (purified) corresponding to Human Properdin/PFC.
Database link: P27918 -
Positive control
- Histology positive control tissue: Kidney from post streptococcal glomerulonephritis patients.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 8.20
Preservative: 0.1% Sodium azide
Constituent: 99% Borate buffered saline -
Concentration information loading...
-
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
10-18 -
Isotype
IgG1 -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab58984 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA | ||
IHC-Fr | ||
Functional Studies |
Notes |
---|
FuncS: Use at an assay dependent dilution.
Note: This antibody inhibits the function of Properdin. Removal of sodium azide is recommended prior to use in functional assays
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
-
Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. -
Involvement in disease
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). -
Sequence similarities
Contains 6 TSP type-1 domains. -
Cellular localization
Secreted. - Information by UniProt
-
Database links
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
-
Alternative names
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab58984 has not yet been referenced specifically in any publications.