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Products:Immunology >> Innate Immunity >> Complement >> Regulatory
Overview
Product name
Anti-Properdin antibody [HYB 039-06]
See all Properdin products (6) ...
Description
Mouse monoclonal [HYB 039-06] to Properdin
Specificity
ab25850 recognises human properdin.
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Properdin isolated from human plasma.
Epitope
Epitope specificity differs from that of ab17780 but slightly overlap as determined by inhibition ELISA.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
HYB 039-06
Myeloma
x63-Ag8.653
Isotype
IgG1
Light chain type
kappa
Research areas
Immunology >> Innate Immunity >> Complement >> Regulatory
Applications
Show applications key
Our Abpromise guarantee covers the use of ab25850 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: 1/8000((based on use as detection antibody for antigen coated at 0.3 µg/ml).)
WB: Use at an assay dependent dilution. (Recognises both reduced and unreduced forms of the protein.)
AP: Use at an assay dependent dilution. (Suitable for affinity purification of human properdin after coupling to an activated CNBr-sepharose column.)
Target
Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Involvement in disease
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
Sequence similarities
Contains 6 TSP type-1 domains.
Cellular localization
Secreted.
Target information above from: UniProt accessionP27918
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
Database links
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
References for Anti-Properdin antibody [HYB 039-06] (ab25850)
ab25850 has not yet been referenced specifically in any publications.
Publishing research using ab25850? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"