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Products:Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Overview
Product name
Anti-Proprotein Convertase 2 antibody - Homo-B domain
See all Proprotein Convertase 2 products (6) ...
Description
Rabbit polyclonal to Proprotein Convertase 2 - Homo-B domain
Specificity
ab28572 recognises the Homo B domain of PC2.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide corresponding to the carboxy end of the Homo B domain of human PC2.
(Peptide available as ab41408.)
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab28572 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT - 1/5000 for chemiluminescent substrates. Predicted molecular weight: 70 kDa. But glycosylation and other post-translational modifications make the pre-pro PC2 run at 75 kDa, the mature PC2 at 71 kDa and carboxy-processed PC2 at 66 kDa. Smaller cleavage products are also detected. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
Sequence similarities
Belongs to the peptidase S8 family. Furin subfamily.
Cellular localization
Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
Target information above from: UniProt accessionP16519
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- KEX2 like endoprotease 2 antibody
- KEX2-like endoprotease 2 antibody
- NEC 2 antibody
see all
Database links
- Entrez Gene: 5126 Human
- Omim: 162151 Human
- SwissProt: P16519 Human
- SwissProt: Q8IWA8 Human
- Unigene: 315186 Human
Protocols
References for Anti-Proprotein Convertase 2 antibody - Homo-B domain (ab28572)
ab28572 has not yet been referenced specifically in any publications.
Publishing research using ab28572? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"