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Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Overview
Product name
Proprotein convertase PC4 peptide (Aminoterminal end)
See all Proprotein convertase PC4 products (2) ...
Protein description
Synthetic peptide PC4. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab28573 - PC4 antibody - Aminoterminal end.
Properties
Purity
>95% by SDS-PAGE
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Concentration
Concentration information loading...
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Proprotein Convertases
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Applications
Show applications key
Our Abpromise guarantee covers the use of ab41410 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution.
Application notes
This peptide can be used with studies using ab28573.
Protein info
Relevance
PC4 was the fifth of the human prohormone convertasae enzymes to be discovered. Like furin, PC1, PC2 and PACE4, PC4 is a serine proteinase that cleaves after pairs of basic amino acids, but with some differences in substrate specificity and distribution. The catalytic domain has homology to other PC enzymes, the prohormone convertase family initially discovered for their role in processing POMC, insulin and other pro-hormones, and later found to process a wider range of precursor proteins. Some have renamed the prohormone convertases as proprotein convertases, and another group has renamed the entire family with a uniform nomenclature of SPCs ( s ubtilisin-like p roprotein c onvertases). PC4 structure contains a propeptide domain, a catalytic domain and an RGD containing cystein-rich domain (homo-B). The PCs have an RxxR consensus cleavage requirement, and the propeptide is separated from the mature protein by just such a sequence. After cleavage of the propeptide domain, PC4 becomes a two-chain form, and the propeptide piece is released after a second internal cleavage.
Cellular localization
Membrane; single pass membrane protein
References for Proprotein convertase PC4 peptide (Aminoterminal end) (ab41410)
ab41410 has not yet been referenced specifically in any publications.
Publishing research using ab41410? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"