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Anti-Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070)

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Overview

Product name

Anti-Prostate Secretory Protein/PSP antibody [YPSP-1]
See all Prostate Secretory Protein/PSP products (4) ...

Description

Mouse monoclonal [YPSP-1] to Prostate Secretory Protein/PSP

Specificity

Does not react with a variety of human normal tissues.

Tested applications

WB, ELISA, ICC/IFmore details

Cross reactivity

Reacts with

Human

Immunogen

Full length protein (purified) (Human).

Positive control

Reactive with PSP or human prostate epithelial cells.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 0.01M PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

YPSP-1

Isotype

IgG1

Research areas

Tags & Cell Markers >> Cell Type Markers >> Other Cell Types
Tags & Cell Markers >> Cell Type Markers >> Epi / Endo-thelial
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated

  • Western blot - Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070)Western blot - Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab19070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

ELISA: Use at an assay dependent dilution.
ICC/IF: Use at a dilution of 1/100.
WB: Use at an assay dependent dilution. Predicted molecular weight: 14 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Tissue specificity

Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.

Involvement in disease

Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:611928]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

Sequence similarities

Belongs to the beta-microseminoprotein family.

Cellular localization

Secreted. Sperm surface.

Target information above from: UniProt accessionP08118 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Beta microseminoprotein [Precursor] antibody
  • Beta-microseminoprotein antibody
  • HPC13 antibody
  • IGBF antibody
  • Immunoglobulin binding factor antibody
  • Immunoglobulin-binding factor antibody
  • Msmb antibody
  • MSMB_HUMAN antibody
  • MSP antibody
  • MSPB antibody
  • PN44 antibody
  • Prostate secreted seminal plasma protein antibody
  • Prostate secretory protein of 94 amino acids antibody
  • Prostate secretory protein PSP94 antibody
  • PRPS antibody
  • PSP 57 antibody
  • PSP antibody
  • PSP-94 antibody
  • PSP57 antibody
  • PSP94 antibody
  • Seminal plasma beta inhibin antibody
  • Seminal plasma beta-inhibin antibody
see all

Database links

Anti-Prostate Secretory Protein/PSP antibody [YPSP-1] images:

  Western blot - Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070)

Western blot - Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070)

Anti-Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070) at 1 µg/ml + Prostate Tumor Lysate Tissue Lysate at 10 µg

Secondary
Goat polyclonal Secondary Antibody to Mouse IgG - H&L (HRP), pre-adsorbed (ab97040) at 1/5000 dilution
developed using the ECL technique

Performed under reducing conditions.

Predicted band size : 14 kDa
Observed band size : 14 kDa
Additional bands at : 45 kDa,54 kDa,74 kDa. We are unsure as to the identity of these extra bands.

Exposure time : 8 minutes

References for Anti-Prostate Secretory Protein/PSP antibody [YPSP-1] (ab19070)

This product has been referenced in:

  • Whitaker HC  et al. The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target. Prostate 70:333-40 (2010).Read more (PubMed: 19790236) »

See 1 publication for this product

Publishing research using ab19070? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"