Prostate Specific Antigen antibody [ER-PR8] (ab39326)

Product Name 

Prostate Specific Antigen antibody [ER-PR8]

Product type 

Primary antibodies

Description 

Mouse monoclonal [ER-PR8] to Prostate Specific Antigen

Immunogen 

Full length native PSA protein (purified) (Human)

Reacts with 
(species key)

Hu

Tested applications 
(see key)

IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-P: 1/25 - 1/100 in an ABC method.
WB: 1/50 - 1/100. Predicted molecular weight: 29 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Prostate carcinoma

Cellular localization 

Cytoplasmic and Secreted

Research areas 

Cancer >> Tumor biomarkers >> Tumor antigens
Cancer >> Tumor immunology >> Tumor-associated antigens
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Neuroscience >> Cell Adhesion Proteins >> Proteases

Relevance 

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

ER-PR8

Isotype 

IgG1

Light chain type 

kappa

Purity 

IgG fraction

Storage buffer 

Preservative: Sodium Azide
Constituents: Tissue culture supernatant

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Storage instructions 

Store at +4°C.

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