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If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Publishing research using ab28663? Please let us know so that we can cite the reference in this datasheet
ab28663 has been referenced in 1 publications.
- Ní Ainle F et al. Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem 286:1323-30 (2011). WB; Human. PubMed: 21044954
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Western blot - Protein C antibody (ab28663)
Predicted band size : 52 kDa
APC and PNGase F-treated APC (PNG-APC, 1 μg) were characterized by 4–15% SDS-PAGE analysis and Western blotting, using ab28663, that detects the protein C/APC heavy chain (HC, shown). For wild type APC, a doublet of ∼35–40 kDa, corresponding to the heavy chains of the two major APC glycoforms, α and β, was identified. PNGase F treatment of APC reduced the molecular mass of the APC doublet ∼10 kDa, corresponding to the disappearance of the fully glycosylated APC heavy chain and the formation of lower molecular mass APC glycoforms upon N-linked glycan proteolysis
Image from Ní Ainle F et al, J Biol Chem. 2011 Jan 14;286(2):1323-30. Epub 2010 Nov 2, Fig 1. DOI 10.1074/jbc.M110.159475
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