Overview

  • Product name
    Proxymetacaine hydrochloride
  • Description
    Neuron voltage-gated sodium channel protein blocker
  • Biological description
    Neuron voltage-gated sodium channel protein blocker (IC50 = 3.4 mM). Induces dose-related spinal blockades of motor function, proprioception and nociception. Shows anesthetic effects in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride
  • Molecular weight
    330.85
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C16H26N2O3.HCl
  • CAS Number
    5875-06-9
  • PubChem identifier
    517321
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 75 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
  • Source

    Synthetic

  • Research areas

    References for Proxymetacaine hydrochloride (ab143687)

    This product has been referenced in:
    • Hung CH  et al. The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats. Anesth Analg 110:238-42 (2010). Read more (PubMed: 19897799) »
    • Wollensak G & Iomdina E Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 35:540-6 (2009). Read more (PubMed: 19251149) »
    • Hung CH  et al. Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett 454:249-53 (2009). Read more (PubMed: 19429093) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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