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Product name
Purvalanol B
Description
CDK2 inhibitor
Biological description
Potent CDK2 inhibitor, displaying an IC50 against the complex of CDK2-cyclin A of 6 nM. Shows selectivity over a range of other protein kinases including protein kinase C, Raf kinase, and casein kinase2.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
4-(2-((R)-1-Hydroxy-3-methylbutan-2-ylamino)-9-isopropyl-9H-purin-6-ylamino)-2-chlorobenzoic acid
Molecular Weight
432.91
Chemical structure
Molecular formula
C20H25ClN6O3
CAS Number
212844-54-7
Solubility
Soluble in 1 eq. NaOH to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Cyclin-dependent kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Purvalanol B (ab120305)
This product has been referenced in:
- Chang YT et al. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem Biol 6:361-75 (1999).Read more (PubMed: 10375538) »
- Gray N et al. ATP-site directed inhibitors of cyclin-dependent kinases. Curr Med Chem 6:859-75 (1999).Read more (PubMed: 10495356) »
See all 3 publications for this product
Publishing research using ab120305? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"