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Anti-QK1 antibody (ab15338)

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Overview

Product name

Anti-QK1 antibody
See all QK1 products (7) ...

Description

Rabbit polyclonal to QK1

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Xenopus laevis

Immunogen

The details of the immunogen for this antibody are not available.

Epitope

The epitope recognized maps to a region between residues 50 and 100 of isoform 5 of human quaking homolog. The epitope is common to isoforms 1, 2, 3, 4, 5, 6, 7 and 7B.

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - QK1 antibody (ab15338)Western blot - QK1 antibody (ab15338) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab15338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.

Tissue specificity

Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.

Sequence similarities

Contains 1 KH domain.

Post-translational
modifications

Methylated by PRMT1.
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.

Cellular localization

Nucleus. Cytoplasm.

Target information above from: UniProt accessionQ96PU8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DKFZp586I0923 antibody
  • HKQ antibody
  • Homolog of mouse quaking QKI KH domain RNA binding protein antibody
  • Hqk antibody
  • HQK1 antibody
  • HqkI antibody
  • OTTHUMP00000017581 antibody
  • OTTHUMP00000017582 antibody
  • OTTHUMP00000017583 antibody
  • Protein quaking antibody
  • QK antibody
  • QK1 antibody
  • QK3 antibody
  • QKI antibody
  • QKI_HUMAN antibody
  • QKI1 antibody
  • Quaking homolog antibody
  • quaking homolog KH domain RNA binding antibody
  • Quaking homolog KH domain RNA binding mouse antibody
  • Quaking isoform 1 antibody
  • Quaking protein antibody
  • RNA binding protein HQK antibody
see all

Anti-QK1 antibody images:

  Western blot - QK1 antibody (ab15338)

Western blot - QK1 antibody (ab15338)

Rabbit polyclonal to QKI (ab15338) at 1/5000.

Lane 1:  20 µg HeLa cell nuclear extract

Detection: chemiluminescence with an exposure time of 15 minutes.

References for Anti-QK1 antibody (ab15338)

ab15338 has not yet been referenced specifically in any publications.

Publishing research using ab15338? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"