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Products:Neuroscience >> Neurology process >> Neural Signal Transduction
Overview
Product name
Anti-QK1 antibody
See all QK1 products (7) ...
Description
Rabbit polyclonal to QK1
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Xenopus laevis
Immunogen
The details of the immunogen for this antibody are not available.
Epitope
The epitope recognized maps to a region between residues 50 and 100 of isoform 5 of human quaking homolog. The epitope is common to isoforms 1, 2, 3, 4, 5, 6, 7 and 7B.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Other
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Splicing
Neuroscience >> Neurology process >> Neural Signal Transduction
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Western blot - QK1 antibody (ab15338)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab15338 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/5000.Detects a band of approximately 39 kDa.
Target
Function
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
Tissue specificity
Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.
Sequence similarities
Contains 1 KH domain.
Post-translational
modifications
Methylated by PRMT1.
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.
Cellular localization
Nucleus. Cytoplasm.
Target information above from: UniProt accessionQ96PU8
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DKFZp586I0923 antibody
- HKQ antibody
- Homolog of mouse quaking QKI KH domain RNA binding protein antibody
see all
Database links
- Entrez Gene: 9444 Human
- Entrez Gene: 19317 Mouse
- Omim: 609590 Human
- SwissProt: Q96PU8 Human
- SwissProt: Q9QYS9 Mouse
- Unigene: 510324 Human
- Unigene: 130694 Mouse
- Unigene: 384135 Mouse
see all
Anti-QK1 antibody images:
Western blot - QK1 antibody (ab15338)
Rabbit polyclonal to QKI (ab15338) at 1/5000.
Lane 1: 20
Detection: chemiluminescence with an exposure time of 15 minutes.
References for Anti-QK1 antibody (ab15338)
ab15338 has not yet been referenced specifically in any publications.
Publishing research using ab15338? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"