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Anti-QK1 antibody (ab78518)

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Overview

Product name

Anti-QK1 antibody
See all QK1 products (7) ...

Description

Rabbit polyclonal to QK1

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide from mouse QK1.

Positive control

Glial cells, astrocytes and oligodendrocytes.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Other
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Splicing
Neuroscience >> Neurology process >> Neural Signal Transduction

Applications

Show applications key

Our Abpromise guarantee covers the use of ab78518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IP

     

Application notes

IP: Use 1 - 2µl.
WB: 1/500 - 1/1000. Predicted molecular weight: 38 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.

Tissue specificity

Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.

Sequence similarities

Contains 1 KH domain.

Post-translational
modifications

Methylated by PRMT1.
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.

Cellular localization

Nucleus. Cytoplasm.

Target information above from: UniProt accessionQ96PU8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DKFZp586I0923 antibody
  • HKQ antibody
  • Homolog of mouse quaking QKI KH domain RNA binding protein antibody
  • Hqk antibody
  • HQK1 antibody
  • HqkI antibody
  • OTTHUMP00000017581 antibody
  • OTTHUMP00000017582 antibody
  • OTTHUMP00000017583 antibody
  • Protein quaking antibody
  • QK antibody
  • QK1 antibody
  • QK3 antibody
  • QKI antibody
  • QKI_HUMAN antibody
  • QKI1 antibody
  • Quaking homolog antibody
  • Quaking homolog KH domain RNA binding antibody
  • Quaking homolog KH domain RNA binding mouse antibody
  • Quaking isoform 1 antibody
  • Quaking protein antibody
  • RNA binding protein HQK antibody
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Database links

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References for Anti-QK1 antibody (ab78518)

ab78518 has not yet been referenced specifically in any publications.

Publishing research using ab78518? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"