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Product name
(R,S)-Rolipram
Description
Selective PDE4 inhibitor
Biological description
Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 µM and 0.17 µM for inhibition of mouse PDE4A1 and PDE4B respectively)
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(R,S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Molecular Weight
275.35
Chemical structure
Molecular formula
C16H21NO3
CAS Number
61413-54-5
Solubility
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Phosphodiesterase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for (R,S)-Rolipram (ab120029)
This product has been referenced in:
- Cherry JA et al. Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochim Biophys Acta 1518:27-35 (2001).Read more (PubMed: 11267656) »
- Zhu J et al. The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev 7:387-98 (2001).Read more (PubMed: 11830756) »
See all 4 publications for this product
Publishing research using ab120029? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"