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- Secondary antibodies
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Product name
Anti-RANTES antibody
See all RANTES products (13) ...
Description
Rabbit polyclonal to RANTES
Tested applications
Cross reactivity
Reacts with
Mouse, Rat
Immunogen
Recombinant fragment, corresponding to amino acids 1-70 of mature Rat RANTES.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Immune System Diseases >> Antiviral Signaling >> HIV-related
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokines (CC)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab7198 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
WB: 1/2000.WB: 1/2000.
Target
Function
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
Tissue specificity
T-cell and macrophage specific.
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family.
Post-translational
modifications
N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Cellular localization
Secreted.
Target information above from: UniProt accessionP13501
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Beta chemokine RANTES precursor antibody
- CCL 5 antibody
- CCL5 antibody
see all
Database links
- Entrez Gene: 20304 Mouse
- Entrez Gene: 81780 Rat
- SwissProt: P30882 Mouse
- SwissProt: P50231 Rat
- Unigene: 8019 Rat
References for Anti-RANTES antibody (ab7198)
ab7198 has not yet been referenced specifically in any publications.
Publishing research using ab7198? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"