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Overview

  • Product nameRANTES proteinSee all RANTES proteins and peptides ...
  • Protein descriptionRecombinant full length Cow RANTES produced in yeast; amino acids 24-91 (68aa), Predicted MWt 7.9kDa (Swiss-Prot O97919).
  • Expression hostSaccharomyces cerevisiae

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab87393 is purified by Ion-exchange chromatography.
  • FormLyophilised:Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
  • Storage instructionsStore at -20°C. Stable for 12 months at -20°C
  • Storage bufferPreservative: None
    Constituents: 10% Trehalose, 1.0X PBS
  • Concentration information loading...
  • Sequence notesSPYASDTTPC CFAYISRPLP RTHVQEYFYT SSKCSMAAVV FITRKNRQVC ANPEKKWVRE YINALELS
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab87393 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Beta chemokine RANTES precursorCCL 5CCL5
        CCL5_HUMANChemokine (C C motif) ligand 5Chemokine CC Motif Ligand 5D17S136EEoCPEosinophil chemotactic cytokineMGC17164RANTES(4-68)Regulated upon activation normally T expressed and presumably secretedSCYA 5SCYA5SIS deltaSIS-deltaSISdSmall inducible cytokine A5Small inducible cytokine A5 (RANTES)Small inducible cytokine subfamily A (Cys Cys) member 5Small-inducible cytokine A5T cell specific protein p288T cell specific RANTES proteinT cell-specific protein P228T-cell-specific protein RANTESTCP 228TCP228
      see all
  • FunctionChemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
  • Tissue specificityT-cell and macrophage specific.
  • Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications    N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
    The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P13501 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for RANTES protein (ab87393)

    ab87393 has not yet been referenced specifically in any publications.

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