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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-RBP4 antibody
See all RBP4 products (11) ...
Description
Goat polyclonal to RBP4
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Rabbit, Horse, Chicken, Cow, Dog, Pig, Chimpanzee, Zebrafish
Immunogen
Synthetic peptide: C-DTEDPAKFKMKY, corresponding to internal sequence amino acids 97-108 of Human RBP4
C-DTEDPAKF KMKY
Positive control
Human liver lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris saline, pH 7.3
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Atherosclerosis >> Diabetes associated
Signal Transduction >> Metabolism >> Vitamins / Minerals
Cardiovascular >> Blood >> Serum Proteins
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Western blot - RBP4 antibody (ab59033)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59033 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
Peptide ELISA: antibody detection limit dilution 1:2,000.
WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 23 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Involvement in disease
Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
Sequence similarities
Belongs to the calycin superfamily. Lipocalin family.
Cellular localization
Secreted.
Target information above from: UniProt accessionP02753
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- OTTHUMP00000020114 antibody
- OTTHUMP00000020115 antibody
- OTTHUMP00000020116 antibody
see all
Database links
- Entrez Gene: 396166 Chicken
- Entrez Gene: 281444 Cow
- Entrez Gene: 5950 Human
- Entrez Gene: 19662 Mouse
- Entrez Gene: 397124 Pig
- Entrez Gene: 25703 Rat
- Entrez Gene: 30077 Zebrafish
- Omim: 180250 Human
see all
Anti-RBP4 antibody images:
Western blot - RBP4 antibody (ab59033)
Anti-RBP4 antibody (ab59033) at 0.3 µg/ml + Human Liver lysate (35µg protein in RIPA buffer)
Predicted band size : 23 kDa
Observed band size : 23 kDa
Primary incubation was 1 hour. Detected by chemiluminescence.
References for Anti-RBP4 antibody (ab59033)
ab59033 has not yet been referenced specifically in any publications.
Publishing research using ab59033? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"