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RBP4 protein (His tag) (ab63267)

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Overview

Product name

RBP4 protein (His tag)
See all RBP4 products (11) ...

Protein description

Recombinant full length RBP4 (Human), total 204 AA, calculated MW 23 kDa, with N terminal His tag and 21 extra AA.

Expression host

E. coli

Properties

Purity

>95% by SDS-PAGE

Purification notes

Endotoxin: <0.5 EU/ug protein.

Form

Liquid

Storage instructions

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS, pH 7.5

Concentration

Concentration information loading...

Sequence notes

MSWWHHHHHH NWNIPTTQDT TERDCRVSSF RVKENFDKAR FSGTWYAMAK KDPEGLFLQD NIVAEFSVDE TGQMSATAKG RVRLLNNWDV CADMVGTFTD TEDPAKFKMK YWGVASFLQK GNDDHWIVDT DYDTYAVQYS CRLLNLDGTC ADSYSFVFSR DPNGLPPEAQ KIVRQRQEEL CLARQYRLIV HNGYCDGRSE RNLL

Research areas

Cardiovascular >> Atherosclerosis >> Diabetes associated
Signal Transduction >> Metabolism >> Vitamins / Minerals
Cardiovascular >> Blood >> Serum Proteins

Applications

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Our Abpromise guarantee covers the use of ab63267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent dilution. Predicted molecular weight: 23 kDa.

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

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    Functional Studies

     FuncS: Use at an assay d...Read more →

    FuncS: Use at an assay dependent dilution. (Binding assay. The binding of RBP4 to all trans retinol acids results in quenching of Trp fluroscence. 0.5 M retinol acids/per M RBP4.)

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    SDS-PAGE

     SDS-PAGE: Use at an ass...Read more →

    SDS-PAGE: Use at an assay dependent dilution.

Protein info

Function

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Involvement in disease

Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Cellular localization

Secreted.

Target information above from: UniProt accessionP02753 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for RBP4 protein (His tag) (ab63267)

ab63267 has not yet been referenced specifically in any publications.

Publishing research using ab63267? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"