Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Overview
Product name
RECK peptide (First spacer region)
See all RECK products (4) ...
Protein description
This peptide was used as an immunogen for ab28271 - RECK antibody - First spacer region.
Properties
Purity
>95% by SDS-PAGE
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Concentration
Concentration information loading...
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> RECK
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab41253 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
ELISA
Application notes
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28271. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Tissue specificity
Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
Sequence similarities
Contains 3 Kazal-like domains.
Post-translational
modifications
N-glycosylated.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionO95980
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for RECK peptide (First spacer region) (ab41253)
ab41253 has not yet been referenced specifically in any publications.
Publishing research using ab41253? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"