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- Primary antibodies
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Product name
RHEB peptide
See all RHEB products (5) ...
Protein description
Synthetic peptide, corresponding to the intermediate domain of human RHEB.
Properties
Purification notes
ab39861 is a crude synthetic peptide, purity range from 60-70%. The sequence is proprietary.
Biological activity
This peptide is used for blocking the activity of the Anti-RHEB antibody (ab25873).
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
Concentration
Concentration information loading...
Research areas
Metabolism >> Types of disease >> Obesity
Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Ras family
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39861 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
Application notes
BL: Use at an assay dependent dilution.
This peptide can be used with studies using ab25873. This peptide usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.
Tissue specificity
Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Sequence similarities
Belongs to the small GTPase superfamily. Rheb family.
Post-translational
modifications
Farnesylation is important for efficiently activating mTORC1-mediated signaling.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionQ15382
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for RHEB peptide (ab39861)
ab39861 has not yet been referenced specifically in any publications.
Publishing research using ab39861? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"