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RING1 peptide (ab32806)

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Overview

Product name

RING1 peptide
See all RING1 products (3) ...

Protein description

Synthetic peptide derived from within residues 1 - 100 of Human RING1. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab32807 - .

Protein length

406 amino acids

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Information available upon request.

Concentration

Concentration information loading...

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Remodeling >> Polycomb Silencing >> PRC1

Applications

Application notes

This peptide can be used with studies using ab32644,ab32644,ab32805 and ab32807.

Protein info

Function

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Contains 1 RING-type zinc finger.

Cellular localization

Nucleus speckle.

Target information above from: UniProt accessionQ06587 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for RING1 peptide (ab32806)

ab32806 has not yet been referenced specifically in any publications.

Publishing research using ab32806? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"