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Anti-RIP antibody (ab2563)

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Overview

Product name

Anti-RIP antibody
See all RIP products (6) ...

Description

Rabbit polyclonal to RIP

Specificity

This antibody detects a 74 kDa protein, corresponding to the apparent molecular weight of RIP on SDS-PAGE immunoblots.

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic peptide mapping to the C-terminus of human RIP

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS pH7.2 with 50% glycerol, 1% BSA and 0.02% sodium azide

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab2563 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 death domain.
Contains 1 protein kinase domain.

Post-translational
modifications

Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.
Autophosphorylated on serine and threonine residues.
Ubiquitinated by 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear-linked type ubiquitin. Polyubiquitination with 'Lys-63'-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of 'Lys-63'-linked chains and polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequently to the termination of the TNF- or Linear polyubiquitinated; the head-to-tail polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated with 'Lys-11'-linked chains.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionQ13546 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Cell death protein RIP antibody
  • FLJ39204 antibody
  • OTTHUMP00000039163 antibody
  • Receptor (TNFRSF) interacting serine threonine kinase 1 antibody
  • receptor interacting protein 1 antibody
  • Receptor interacting protein antibody
  • Receptor interacting serine threonine protein kinase 1 antibody
  • Receptor interacting serine threonine protein kinase 2 antibody
  • Receptor TNFRSF interacting serine threonine kinase 1 antibody
  • Receptor-interacting protein 1 antibody
  • Receptor-interacting serine/threonine-protein kinase 1 antibody
  • Rinp antibody
  • RIP 1 antibody
  • RIP antibody
  • Rip-1 antibody
  • RIP1 antibody
  • RIPK 1 antibody
  • RIPK1 antibody
  • RIPK1_HUMAN antibody
  • Serine threonine protein kinase RIP antibody
  • Serine/threonine-protein kinase RIP antibody
see all

References for Anti-RIP antibody (ab2563)

ab2563 has not yet been referenced specifically in any publications.

Publishing research using ab2563? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"