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Anti-RLA DQ antibody [2C4] (Phycoerythrin) (ab25538)

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Overview

Product name

Anti-RLA DQ antibody [2C4] (Phycoerythrin)
See all RLA DQ products (3) ...

Description

Mouse monoclonal [2C4] to RLA DQ (Phycoerythrin)

Conjugation

Phycoerythrin

Specificity

ab25538 reacts with rabbit RLA-DQ alpha chain

Tested applications

Flow Cyt, IHC-Fr, IPmore details

Cross reactivity

Reacts with

Rabbit

Immunogen

Tissue / cell preparation (Rabbit) - rabbit spleen cells.

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark. Do not freeze.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: 16% Sucrose, PBS and stabilizing agent.

Concentration

Concentration information loading...

Purity

IgG fraction

Primary antibody notes

ab25538 reacts with RLA-DQ-transfected cells, but not with RLA-DR-transfected cells. In normal adult rabbits, the antibody reacts with 30-60% of peripheral blood leukocytes.

Clonality

Monoclonal

Clone number

2C4

Isotype

IgG2a

Light chain type

kappa

Research areas

Immunology >> Adaptive Immunity >> MHC >> Class II

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25538 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

In normal adult rabbits, this antibody reacts with 30-60% of peripheral blood leukocytes. It has also been reported that the antibody stains: lymphocytes and macrophages in the spleen; lymphocytes in the thymic medulla and some cells in the cortex; Kupffer cells in the liver; and synovial lining cells in inflamed synovium. DQ? transcripts have been detected in bone marrow and spleen and, to a lesser extent, in appendix, lymph nodes, and other organs.

Cellular localization

Cell Membrane

Alternative names

  • MHC class II antigen [Fragment] antibody
  • MHC class II antigen antibody
  • RLA DQA antibody

Database links

References for Anti-RLA DQ antibody [2C4] (Phycoerythrin) (ab25538)

This product has been referenced in:

  • Wilkinson JMet al. Immunohistochemical identification of leucocyte populations in normal tissue and inflamed synovium of the rabbit. J Pathol 170:315-20 (1993).Read more (PubMed: 8133406) »
  • Spieker-Polet Het al. Rabbit major histocompatibility complex. IV. Expression of major histocompatibility complex class II genes. J Immunogenet 17:123-32 (1990).Read more (PubMed: 2120349) »

See all 3 publications for this product

Publishing research using ab25538? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"