Overview

  • Product name
  • Description
    Rabbit polyclonal to ROR beta
  • Host species
    Rabbit
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Hamster, Cow, Dog, Monkey, Gorilla, Bat
  • Immunogen

    Synthetic peptide corresponding to Human ROR beta. The peptide corresponds to 20 amino acids, of the ligand-binding domain. (NP_008845.2)
    Database link: Q92753

  • Positive control
    • Human brain thalamus tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA133M9.1 antibody
    • NR1F2 antibody
    • Nuclear receptor ROR-beta antibody
    • Nuclear receptor RZR beta antibody
    • Nuclear receptor RZR-beta antibody
    • Nuclear receptor subfamily 1 group F member 2 antibody
    • OTTHUMP00000021486 antibody
    • RAR related orphan receptor B antibody
    • RAR related orphan receptor beta antibody
    • Retinoic acid binding receptor beta antibody
    • Retinoid-related orphan receptor-beta antibody
    • ROR BETA antibody
    • Rorb antibody
    • RORB_HUMAN antibody
    • RZR BETA antibody
    • RZRB antibody
    see all

Images

  • Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human brain thalamus tissue labeling ROR beta with ab88756 at 5 µg/ml.

References

This product has been referenced in:
  • Wang RX  et al. Melatonin downregulates nuclear receptor RZR/ROR? expression causing growth-inhibitory and anti-angiogenesis activity in human gastric cancer cells in vitro and in vivo. Oncol Lett 12:897-903 (2016). IHC ; Mouse . Read more (PubMed: 27446366) »

See 1 Publication for this product

Customer reviews and Q&As

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry (PFA perfusion fixed frozen sections)
Sample
Mouse Tissue sections (Brain)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: 10mM Sodium Citrate
Permeabilization
Yes - 0.3% Triton X-100
Specification
Brain
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 18°C
Fixative
Formaldehyde
Username

Mr. Yasushi Nakagawa

Verified customer

Submitted Dec 18 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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