Recombinant
RabMAb

Anti-ROR2 antibody [EPR19980] (ab218105)

Overview

  • Product name
    Anti-ROR2 antibody [EPR19980]
    See all ROR2 primary antibodies
  • Description
    Rabbit monoclonal [EPR19980] to ROR2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human ROR2 aa 1-250. The exact sequence is proprietary.
    Database link: Q01974

  • Positive control
    • IHC-P: Human breast, breast cancer, pancreas, pancreatic cancer, bladder cancer and gastrointestinal stromal tumors tissues.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab218105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Antigen Retrieval Buffer (100X Tris-EDTA Buffer, pH 9.0) (ab93684)

Target

  • Function
    Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.
  • Involvement in disease
    Brachydactyly B1
    Robinow syndrome autosomal recessive
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
    Contains 1 FZ (frizzled) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 kringle domain.
    Contains 1 protein kinase domain.
  • Developmental stage
    Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BDB antibody
    • BDB1 antibody
    • Brachydactyly type B antibody
    • EC 2.7.10.1 antibody
    • MGC163394 antibody
    • Neurotrophic tyrosine kinase antibody
    • Neurotrophic tyrosine kinase, receptor related 2 antibody
    • NTRKR2 antibody
    • Receptor tyrosine kinase-like orphan receptor 2 antibody
    • receptor-related 2 antibody
    • ROR2 antibody
    • ROR2_HUMAN antibody
    • Tyrosine protein kinase transmembrane receptor ROR2 antibody
    • Tyrosine-protein kinase transmembrane receptor Ror2 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded human breast tissue labeling ROR2 with ab218105 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

    Positive membranous staining on human breast stroma cells; negative staining on epithelium cells.

    Counter stained with Hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

  • Immunohistochemical analysis of paraffin-embedded human breast cancer tissue labeling ROR2 with ab218105 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

    Membranous staining on human breast cancer is observed.

    Counter stained with Hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue labeling ROR2 with ab218105 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

    Positive membranous staining on human pancreas blood vessels; negative staining on epithelium cell.

    Counter stained with Hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

  • Immunohistochemical analysis of paraffin-embedded human pancreatic cancer tissue labeling ROR2 with ab218105 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

    Membranous staining on human pancreatic cancer is observed.

    Counter stained with Hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

  • Immunohistochemical analysis of paraffin-embedded human bladder cancer tissue labeling ROR2 with ab218105 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

    Membranous staining on human bladder cancer is observed.

    Counter stained with Hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

  • Immunohistochemical analysis of paraffin-embedded human gastrointestinal stromal tumors labeling ROR2 with ab218105 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

    Cytoplasmic membrane staining on human gastrointestinal stromal tumors is observed.

    Counter stained with Hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

References

ab218105 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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