Anti-RRN3 (phospho S649) antibody (ab138651)
Key features and details
- Rabbit polyclonal to RRN3 (phospho S649)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-RRN3 (phospho S649) antibody
See all RRN3 primary antibodies -
Description
Rabbit polyclonal to RRN3 (phospho S649) -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Extracts from starved Jurkat cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab138651 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab138651 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 74 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 74 kDa. |
Target
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Function
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction. -
Sequence similarities
Belongs to the RRN3 family. -
Post-translational
modificationsPhosphorylation is required for participation in rDNA transcription. -
Cellular localization
Nucleus > nucleolus. - Information by UniProt
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Database links
- Entrez Gene: 54700 Human
- Omim: 605121 Human
- SwissProt: Q9NYV6 Human
- Unigene: 460078 Human
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Alternative names
- AL023001 antibody
- DKFZp566E104 antibody
- E130302O19Rik antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab138651 has been referenced in 2 publications.
- Fyfe JJ et al. Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training. Sci Rep 8:560 (2018). PubMed: 29330460
- Jurmeister S et al. Identification of potential therapeutic targets in prostate cancer through a cross-species approach. EMBO Mol Med N/A:N/A (2018). WB . PubMed: 29437778