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Product Name
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Rab11A antibody
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See all Rab11A antibodies (4)...
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Product type
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Primary antibodies
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Description
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Goat polyclonal to Rab11A
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Immunogen
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Synthetic peptide: TENKPKVQCCQNI, corresponding to C terminal amino acids 204-216 of Human Rab11A.
BLAST 'TENKPKVQCCQNI' with  or 
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Reacts with
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Ms
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Predicted to react
(species key)
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Hu
(Due to sequence homology)
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Western Blot – Approx 25-28kDa band seen in Mouse Heart lysate (predicted MW 25kDa). Recommended for use at 1.0-3.0ug/ml.
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Positive control
(see definition)
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Mouse Heart lysate
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Cellular localization
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Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
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Research areas
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Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Ras family
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
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Relevance
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Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, Rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There are over 40 Rab proteins in mammals. Rab11a and Rab11b are known markers for protein trafficking, sorting, and recycling in the endosomal pathway. The Rab11 proteins are enriched in recycling endosomes and the trans-Golgi network, where they regulate membrane recycling back to the plasma membrane. Rab11a is ubiquitously expressed, while Rab11b is expressed mainly in the heart and brain.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Goat
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Principal Names – RAB11A; YL8; RAB11A, member RAS oncogene family; RAB 11A, member oncogene family
Official Gene Symbol - RAB11A
GenBank Accession Number – NP_004654
LocusLink ID - 55072 (human)
Gene Ontology terms - RAB small monomeric GTPase
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Rab11A antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Rab11A
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Rab11A antibody - more information
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Customer reviews (feedback) regarding Rab11A antibody |
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