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Anti-Rab5b antibody (ab74907)

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Overview

Product name

Anti-Rab5b antibody
See all Rab5b products (3) ...

Description

Rabbit polyclonal to Rab5b

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Human

Predicted to work with

Rat

Immunogen

Synthetic peptide from the internal part of human Rab5b conjugated to an immunogenic carrier protein

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Neuroscience >> Neurotransmission >> Secretory Vesicles >> Rabs
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab74907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IHC-P

     

  • IHC-Fr

     

Application notes

IHC-P: 1/300 - 1/2000. Antigen retrieval recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 24 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Rab5b is a member of the Rab family of small (monomeric) G proteins. Like other small G proteins, Rab5b switches between an inactive, GDP-form and an active, GTP-bound form. GDP/GTP exchange factors (GEFs) catalyse the conversion from the GDP-bound form to the GTP-bound form, while GTPase-activating proteins (GAPs) catalyse GTP hydrolysis to GDP. Rab5b is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of Rab5b abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection. Furthermore, Rab5b interacts with LRRK2, the defective gene at the PARK8 locus that results in Parkinson's disease. Roles for Rab5b in neurodegenerative disease, neuroprotection, and synaptic plasticity have been suggested.

Cellular localization

Cell Membrane

Alternative names

  • Rab 5b antibody
  • Rab5 b antibody
  • RAB5B, member RAS oncogene family antibody
  • Ras related protein Rab 5B antibody

Database links

References for Anti-Rab5b antibody (ab74907)

ab74907 has not yet been referenced specifically in any publications.

Publishing research using ab74907? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"