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Product Name
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Rad51 antibody [Rad51 3C10]
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See all Rad51 antibodies (15)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [Rad51 3C10] to Rad51
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Immunogen
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Recombinant full length protein (Human)
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Reacts with
(species key)
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Hu, Cow, Pig
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 37 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.
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Relevance
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Rad51 is a recombinase that is essential for homologous recombination and double-strand break repair. It binds to single and double-stranded DNA, and has DNA-dependent ATPase activity. Rad51 unwinds duplex DNA and forms helical nucleoprotein filaments in a manner that is controlled through the action of DNA helicases that counteract nucleofilament formation. Rad51 interacts with BRCA1 and BRCA2, and also plays a role in p53-mediated signalling. Interaction of Rad51 with Chk1 kinase may occur in response to Chk1 phosphorylation.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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Rad51 3C10
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Myeloma
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Sp2
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Isotype
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IgG1
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Purity
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IgG fraction
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Storage buffer
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Preservative: None
Constituents: PBS
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Form
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Liquid
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Concentration
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Batch dependent within range: 1.12 - 1.12 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Rad51 antibody [Rad51 3C10] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Rad51 antibody [Rad51 3C10] (ab20240)
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This product has been used in: (two most recent references)
Masson JY et al. The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51. EMBO J 18:6552-60 (1999). PubMed: 10562567
Barlow AL et al. Distribution of the Rad51 recombinase in human and mouse spermatocytes. EMBO J 16:5207-15 (1997). PubMed: 9311981
If you publish research using ab20240 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Rad51
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Rad51 antibody [Rad51 3C10] - more information
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Contact Abcam with a Technical Enquiry about Rad51 antibody [Rad51 3C10] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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