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Product Name
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Rad51L1 antibody [1 H3/13]
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See all Rad51L1 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [1 H3/13] to Rad51L1
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Immunogen
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His-tagged hRAD51L1, overexpressed in E. coli.
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Reacts with
(species key)
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Hu
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Specificity
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ab3637 recognizes human Rad51L1. Other species have not been tested. ab3637 does not cross-react with Rad51C, Rad51D, Rad51, XRCC2, or XRCC3 in Western analysis.
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 42 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.
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Relevance
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Rad51L1, also known as Rad51B, plays a role in the homologous recombination of double-stranded DNA breaks arising during DNA replication or resulting from exposure to DNA damaging agents. Rad51L1 may promote the assembly of Rad51 nucleoprotein filaments at these sites. the Rad51L1/Rad51C heterodimer exhibits single stranded DNA-dependent ATPase activity. Rad51L1 is a component of the BCDX2 complex, which also contains Rad51C, Rad51D and XRCC2. The BCDX2 complex binds to single-stranded DNA, single-stranded gaps in duplex DNA, and to nicks in duplex DNA. Overexpression of Rad51L1 causes G1 delay and apoptosis, consistent with its role in sensing DNA damage.
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Rad51L1 antibody [1 H3/13] (ab3637) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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1 H3/13
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Purity
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Ascites
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: Ascites Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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8.400 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Rad51L1 antibody [1 H3/13] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Rad51L1 antibody [1 H3/13] (ab3637)
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This product has been used in: (two most recent references)
Gildemeister OS et al. Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. J Biol Chem 284:31945-52 (2009). WB; Human. PubMed: 19783859
Masson JY et al. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Genes Dev 15:3296-307 (2001). PubMed: 11751635
See all 3 publication references for this product.
If you publish research using ab3637 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Rad51L1
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Rad51L1 antibody [1 H3/13] - more information
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