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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.
Overview
Product name
Anti-Rad51L1 antibody [RAD51B 1E11/6]
See all Rad51L1 products (8) ...
Description
Mouse monoclonal [RAD51B 1E11/6] to Rad51L1
Specificity
Recognises as little as 10 ng of purified protein. Does not cross-react with Rad51C, Rad51D, Rad51, XRCC2 or XRCC3 in westerns.
Tested applications
Cross reactivity
Reacts with
Hamster, Human
Immunogen
His-tagged human Rad51L1
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
Purified on a talon affinity column under denaturing conditions, followed by gel purification on a SDS-PAGE.
Clonality
Monoclonal
Clone number
RAD51B 1E11/6
Myeloma
Sp2/0-Ag14
Isotype
unknown
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11050 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 42 kDa.
Target
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Tissue specificity
Expressed in a wide range of tissues.
Involvement in disease
Note=A chromosomal aberration involving RAD51L1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1.
Note=A chromosomal aberration involving RAD51L1 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2.
Sequence similarities
Belongs to the RecA family. RAD51 subfamily.
Cellular localization
Nucleus.
Target information above from: UniProt accessionO15315
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DNA repair protein RAD51 homolog 2 antibody
- hREC2 antibody
- MGC34245 antibody
see all
Database links
- Entrez Gene: 5890 Human
- Omim: 602948 Human
- SwissProt: O15315 Human
- Unigene: 172587 Human
References for Anti-Rad51L1 antibody [RAD51B 1E11/6] (ab11050)
This product has been referenced in:
- French CAet al. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem 277:19322-30 (2002).Read more (PubMed: 11912211) »
See 1 publication for this product
Publishing research using ab11050? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"