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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.
Overview
Product name
Anti-Rad51L1 antibody [Rad51B 1H3/13]
See all Rad51L1 products (8) ...
Description
Mouse monoclonal [Rad51B 1H3/13] to Rad51L1
Specificity
Does not recognise Rad51C in total HeLa extracts.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length protein (Human) that has been his-tagged and overexpressed in e.coli.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
The antibody was purified on a talon affinity column under denaturing conditions, followed by gel purification on a SDS-Page.
Clonality
Monoclonal
Clone number
Rad51B 1H3/13
Myeloma
Sp2/0-Ag14
Isotype
IgG2a
Light chain type
unknown
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab20242 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 38 kDa.
Target
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Tissue specificity
Expressed in a wide range of tissues.
Involvement in disease
Note=A chromosomal aberration involving RAD51L1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1.
Note=A chromosomal aberration involving RAD51L1 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2.
Sequence similarities
Belongs to the RecA family. RAD51 subfamily.
Cellular localization
Nucleus.
Target information above from: UniProt accessionO15315
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DNA repair protein RAD51 homolog 2 antibody
- hREC2 antibody
- MGC34245 antibody
see all
Database links
- Entrez Gene: 5890 Human
- Omim: 602948 Human
- SwissProt: O15315 Human
- Unigene: 172587 Human
References for Anti-Rad51L1 antibody [Rad51B 1H3/13] (ab20242)
ab20242 has not yet been referenced specifically in any publications.
Publishing research using ab20242? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"