Anti-Radixin antibody [AF1H1] (ab85323)

Function

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

Involvement in disease

Defects in RDX are the cause of deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Sequence similarities

Contains 1 FERM domain.

Domain

The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN.

Post-translational
modifications

Phosphorylated by tyrosine-protein kinases.

Cellular localization

Cell membrane. Cytoplasm > cytoskeleton. Cleavage furrow. Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.

Alternative names

Database links