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Product Name
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Raf1 antibody [410]
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See all Raf1 antibodies (28)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [410] to Raf1
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Immunogen
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Purified recombinant human Raf-1 (mw:75 kDa).
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Reacts with
(species key)
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Hu
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Specificity
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This antibody is specifically reactive to Raf-1 N-terminal (1-240 a.a.)
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
This antibody, at a concentration of 1.0 µg/ml, will allow visualization of 0.2 µg/lane of human Raf-1.
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Cellular localization
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Mitochondrial outer membrane
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Research areas
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Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Growth factor receptors
Cell Biology >> Apoptosis >> Mitochondrial
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
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Relevance
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The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase (also known as Raf1) is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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410
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Isotype
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IgG1
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Light chain type
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kappa
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Storage buffer
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n/a
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Purification notes
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Affinity purified from ascitic fluid.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Raf1 antibody [410] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Raf1
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Raf1 antibody [410] - more information
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Customer reviews (feedback) regarding Raf1 antibody [410] |
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