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Read our guarantee »Products:Cell Biology >> Cell Cycle >> Cell Division >> Spindle
Anti-Ran antibody [ARAN1]
See all Ran products (9) ...
Mouse monoclonal [ARAN1] to Ran
WB, IP, ELISA, ICCmore details
Reacts with
Mouse, Hamster, Cow, Human, Xenopus laevis
Denatured recombinant protein (Human).
The antibody epitope is located at the C-terminus (amino acids 207-216), which is highly negatively charged.
Jurkat cells extract.
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
Concentration information loading...
Protein A purified
This antibody is purified from culture supernatant of hybridoma cells, grown in a bioreactor.
Monoclonal
ARAN1
IgG2b
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Nuclear Pore Complex
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Cell Biology >> Cell Cycle >> Cell Division >> Spindle
Our Abpromise guarantee covers the use of ab13049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml.Predicted molecular weight: 25 kDa.
IP: Use at an assay dependent dilution.
ELISA: Use at an assay dependent dilution.
ICC: Use at an assay dependent dilution.
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Expressed in a variety of tissues.
Belongs to the small GTPase superfamily. Ran family.
The N-terminus is blocked.
Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target information above from: UniProt accessionP62826
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab13049 has not yet been referenced specifically in any publications.
Publishing research using ab13049? Please let us know so that we can cite the reference in this datasheet
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