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Products:Cell Biology >> Cell Cycle >> Cell Division >> Spindle
Overview
Product name
Anti-Ran antibody
See all Ran products (9) ...
Description
Rabbit polyclonal to Ran
Tested applications
WB, IFmore details
Cross reactivity
Reacts with
Saccharomyces cerevisiae
Immunogen
Recombinant fusion protein (S. cerevisiae).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: Whole Serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Nuclear Pore Complex
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Cell Biology >> Cell Cycle >> Cell Division >> Spindle
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Western blot - Ran antibody (ab11693)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11693 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).
IF
IF: 1/1000IF: 1/1000
Target
Function
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Tissue specificity
Expressed in a variety of tissues.
Sequence similarities
Belongs to the small GTPase superfamily. Ran family.
Post-translational
modifications
The N-terminus is blocked.
Cellular localization
Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target information above from: UniProt accessionP62826
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Androgen receptor associated protein 24 antibody
- Androgen receptor-associated protein 24 antibody
- ARA 24 antibody
see all
Anti-Ran antibody images:
Western blot - Ran antibody (ab11693)
Predicted band size : 26 kDa
ab11693 at a 1/1000 dilution staining approximately 25kDa Ran in S.cerevisiae whole cell lysate by Western blot (ECL).
References for Anti-Ran antibody (ab11693)
This product has been referenced in:
- Muniyappa MKet al. MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. Eur J Cancer 45:3104-18 (2009). WB; Human.Read more (PubMed: 19818597) »
See 1 publication for this product
Publishing research using ab11693? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"