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Anti-Ran antibody (ab31118)

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Overview

Product name

Anti-Ran antibody
See all Ran products (9) ...

Description

Rabbit polyclonal to Ran

Tested applications

WB, IHC-Pmore details

Cross reactivity

Reacts with

Mouse, Human

Predicted to work with

Rat

Immunogen

Synthetic peptide: EHDLEVAQTTALPDEDDDL, corresponding to amino acids 197-216 of Human Ran

EHDLEVAQTT ALPDEDDDL

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

HeLa and A431 cells. Normal breast

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Nuclear Pore Complex
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Cell Biology >> Cell Cycle >> Cell Division >> Spindle

  • Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - Ran antibody (ab31118)Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - Ran antibody (ab31118) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab31118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent dilution. Predicted molecular weight: 24 kDa.

  • ShowHide1 Image

    IHC-P

     IHC-P: 1/50Perform heat ...Read more →

    IHC-P: 1/50Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

Function

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Tissue specificity

Expressed in a variety of tissues.

Sequence similarities

Belongs to the small GTPase superfamily. Ran family.

Post-translational
modifications

The N-terminus is blocked.

Cellular localization

Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Target information above from: UniProt accessionP62826 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Androgen receptor associated protein 24 antibody
  • Androgen receptor-associated protein 24 antibody
  • ARA 24 antibody
  • ARA24 antibody
  • Gsp1 antibody
  • GTP binding nuclear protein RAN antibody
  • GTP-binding nuclear protein Ran antibody
  • GTPase Ran antibody
  • LPS antibody
  • ran antibody
  • RAN member RAS oncogene family antibody
  • RAN_HUMAN antibody
  • Ras like protein TC4 antibody
  • Ras related nuclear protein antibody
  • Ras-like protein TC4 antibody
  • Ras-related nuclear protein antibody
  • RASL2 8 antibody
  • TC 4 antibody
  • TC4 antibody
see all

Database links

see all

Anti-Ran antibody images:

  Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - Ran antibody (ab31118)

Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - Ran antibody (ab31118)

Human breast stained with ab31118 at a 1/50 dilution

References for Anti-Ran antibody (ab31118)

This product has been referenced in:

  • Graham JDet al. DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology 150:3318-26 (2009). IHC-P; Human.Read more (PubMed: 19342456) »
  • Sepp KJet al. Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet 4:e1000111 (2008). ICC/IF; Mouse.Read more (PubMed: 18604272) »

See all 2 publications for this product

Publishing research using ab31118? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"