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Ran protein (Mutated G19 V + Q69L) (Human) (ab90724)

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Overview

  • Product nameRan protein (Mutated G19 V + Q69L) (Human)See all Ran proteins and peptides ...
  • Protein descriptionRecombinant fragment of human transcription factor FKHR (KISGRLSPIMTEQ, aa 324-334) with two lysine residues added at the N-terminus to facilitate binding to phosphocellulose paper. Molecular Weight: 1588 g/mol. Swiss-Prot Q12778.
  • Expression hostE. coli

    • Properties

  • Purification notesPurity: 90 - 95% by HPLC
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Sequence notesKKISGRLSPIMTEQ
  • Research Areas

    • Protein info

    • Alternative names
        Androgen receptor associated protein 24Androgen receptor-associated protein 24ARA 24
        ARA24Gsp1GTP binding nuclear protein RANGTP-binding nuclear protein RanGTPase RanGuanosine triphosphatase RanLPSOK/SW-cl.81ranRAN member RAS oncogene familyRAN_HUMANRanGTPaseRas like protein TC4Ras related nuclear proteinRas-like protein TC4Ras-related nuclear proteinRASL2 8TC 4TC4
      see all
  • FunctionGTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • Tissue specificityExpressed in a variety of tissues.
  • Sequence similaritiesBelongs to the small GTPase superfamily. Ran family.
  • Post-translational
    modifications    The N-terminus is blocked.
  • Cellular localizationNucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    • Target information above from: UniProt accession P62826 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Ran protein (Mutated G19 V + Q69L) (Human) (ab90724)

    ab90724 has not yet been referenced specifically in any publications.

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