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Product Name
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Rapsyn antibody [1234]
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See all Rapsyn antibodies (2)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [1234] to Rapsyn
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Immunogen
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Whole purified rapsyn from Torpedo californica electric organ postsynaptic membrane.
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Reacts with
(species key)
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Ms, Rat, Amph, Chk, Fsh
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Tested applications
(see key)
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ICC/IF, IHC-Fr, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ICC: Use at an assay dependent dilution.
IF: Use at a concentration of 2 µg/ml.
IHC-Fr: Use at an assay dependent dilution.
WB: Use at a concentration of 0.5 µg/ml. Detects a band of approximately 48 kDa, representing rapsyn from Torpedo californica electrocyte cell extracts.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Torpedo californica electrocyte cell extracts.
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Cellular localization
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Cytoplasmic surface of postsynaptic membranes.
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse.
Note: cytoplasmic surface of postsynaptic membranes.
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Research areas
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Neuroscience >> Neurotransmission >> Receptors / Channels >> Ligand-Gated Ion Channels >> nAch Receptors
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Relevance
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Nicotinic acetylcholine receptors (AChRs) are organized into high-density postsynaptic clusters at the motor endplate that are critical for efficient synaptic transmission. The organization of AChRs is carried out by the 43 kDa cytoplasmic protein rapsyn. Studies have indicated that mutations which impair the activity of rapsyn can lead to the formation of congenital myasthenic syndrome (CMS). CMS is characterized by poor development of the postsynaptic region.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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1234
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Isotype
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IgG1
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.05% Sodium Azide
Constituents: PBS, 1mg/ml BSA Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Rapsyn antibody [1234] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Rapsyn antibody [1234] (ab11423)
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This product has been used in: (two most recent references)
Cossins J et al. Diverse molecular mechanisms involved in AChR deficiency due to rapsyn mutations. Brain 129:2773-83 (2006). PubMed: 16945936
Stetzkowski-Marden F et al. Agrin elicits membrane lipid condensation at sites of acetylcholine receptor clusters in C2C12 myotubes. J Lipid Res 47:2121-33 (2006). PubMed: 16816402
If you publish research using ab11423 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Rapsyn
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