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Product name
Rasagiline mesylate
Description
MAO-B inhibitor
Alternative names
- Azilect
Biological description
Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-Inden-1-amine methanesulfonate
Molecular Weight
267.34
Chemical structure
Molecular formula
C12H13N.CH3SO3
CAS Number
161735-79-1
Solubility
Soluble in water to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Oxidases >> MAO >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water
References for Rasagiline mesylate (ab120236)
This product has been referenced in:
- Weinreb O et al. Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain. J Neural Transm 116:1457-72 (2009).Read more (PubMed: 19396396) »
- Mandel S et al. Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives. Brain Res Brain Res Rev 48:379-87 (2005).Read more (PubMed: 15850677) »
See all 3 publications for this product
Publishing research using ab120236? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"