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Product name
Anti-Rb2 p130 antibody [KAB40]
See all Rb2 p130 products (8) ...
Description
Mouse monoclonal [KAB40] to Rb2 p130
Specificity
Recognizes both phosphorylated and non-phosphorylated forms of p130 by immunoblotting.
Tested applications
Cross reactivity
Reacts with
Mouse, Donkey, Human
Immunogen
Recombinant fusion protein (Human).
Positive control
CC3A whole cell lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.08% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
KAB40
Isotype
IgG1
Research areas
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Rb family
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Rb
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Rb
Applications
Show applications key
Our Abpromise guarantee covers the use of ab10576 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000. Detects a band of approximately 130 kDa (predicted molecular weight: 128 kDa).
Target
Relevance
Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
Cellular localization
Nuclear
Alternative names
- 130 kDa retinoblastoma associated protein antibody
- FLJ26459 antibody
- p130 antibody
see all
Database links
- Entrez Gene: 5934 Human
- Entrez Gene: 19651 Mouse
- Omim: 180203 Human
- SwissProt: Q08999 Human
- SwissProt: 235580 Mouse
- SwissProt: Q64700 Mouse
- Unigene: 283604 Human
References for Anti-Rb2 p130 antibody [KAB40] (ab10576)
ab10576 has not yet been referenced specifically in any publications.
Publishing research using ab10576? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"