Probably involved in connections of major cytoskeletal structures to the plasma membrane.
In all tissues and cultured cells studied.
Contains 1 FERM domain.
Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.
Cell membrane. Cytoplasm > cytoskeleton. Apical cell membrane. Cell projection > microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.