Recombinant Human Nkx3.1 protein (ab114523)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      GSYLLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYL SAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPA LKEEAFSRAS
    • Molecular weight
      38 kDa including tags
    • Amino acids
      100 to 209

Associated products

Specifications

Our Abpromise guarantee covers the use of ab114523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • BAPX 2
    • BAPX2
    • Homeobox protein NK-3 homolog A
    • Homeobox protein Nkx 3.1
    • Homeobox protein Nkx-3.1
    • Homeobox protein Nkx3.1
    • NK homeobox (Drosophila) family 3 A
    • NK homeobox family 3 A
    • NK homeobox, family 3, member A
    • NK3 homeobox 1
    • NK3 transcription factor homolog A
    • NK3 transcription factor related locus 1
    • NKX 3
    • Nkx 3.1
    • NKX 3A
    • NKX3
    • NKX3 1
    • Nkx3-1
    • NKX3.1
    • Nkx3.1, mouse, homolog of
    • NKX31_HUMAN
    • NKX3A
    see all
  • Function
    Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
  • Tissue specificity
    Highly expressed in the prostate and, at a lower level, in the testis.
  • Sequence similarities
    Belongs to the NK-3 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Post-translational
    modifications
    Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab114523 at approximately 37.73kDa stained with Coomassie Blue.

References

ab114523 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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