Anti-Rffl antibody (ab57316)

Overview

• Product nameAnti-Rffl antibodySee all Rffl primary antibodies ...
• Description
  Mouse monoclonal to Rffl
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant fragment: WATCCNWFCL DGQPEEVPPP QGARMQAYSN PGYSSFPSPT GLEPSCKSCG AHFANTARKQ TCLDCKKNFC MTCSSQVGNG PRLCLLCQRF RATAFQRE, corresponding to amino acids 2-100 of Human Rffl

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2a
• Light chain typekappa
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • NFkB Pathway

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • NFkB pathway

  • Epigenetics and Nuclear Signaling
  • Ubiquitin & Ubiquitin Like Modifiers
  • E3 Ubiquitin Ligases

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Ubiquitin E2s and E3s
  • Other E3 Ligases

  • Cell Biology
  • Apoptosis
  • Intracellular
  • p53 Pathway

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Caspases etc
  • Inhibitors

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Survivin / IAPs

Applications

Target

• FunctionHas E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
• Tissue specificityUbiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
• PathwayProtein modification; protein ubiquitination.
• Sequence similaritiesContains 1 FYVE-type zinc finger.
  Contains 1 RING-type zinc finger.
  Contains 2 SAP domains.
• Post-translational
  modificationsRapidly degraded after stimulation with TNFSF10, probably by caspases.
  Auto-ubiquitinated (in vitro).
  Palmitoylated.
• Cellular localizationCytoplasm. Membrane.

Target information above from: UniProt accession Q8WZ73 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 117584 Human
  • Omim: 609735 Human
  • SwissProt: Q8WZ73 Human
  • Unigene: 13680 Human

• Alternative names
  CARP-2 antibodyCARP2 antibodyCaspase regulator CARP2 antibody

  Caspases 8 and 10 associated RING finger protein 2 antibodycaspases-8 and -10- associated RING finger protein 2 antibodyCaspases-8 and -10-associated RING finger protein 2 antibodyE3 ubiquitin protein ligase rififylin antibodyE3 ubiquitin-protein ligase rififylin antibodyFring antibodyFYVE RING finger protein Sakura antibodyFYVE-RING finger protein Sakura antibodyRffl antibodyRFFL_HUMAN antibodyRififylin antibodyRING finger and FYVE like domain containing protein antibodyRING finger and FYVE-like domain-containing protein 1 antibodyRING finger protein 189 antibodyRING finger protein 34 like antibodyRING finger protein 34-like antibodyRNF189 antibodyRNF34L antibody

  see all

Anti-Rffl antibody images

• 

  Western blot - Rffl antibody (ab57316)
  Western blot against tagged recombinant protein immunogen using ab57316 Rffl antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa