Overview

  • Product nameRiluzole (PK 26124)
  • Description
    Neuroprotective agent. Modulates glutamate transmission.
  • Alternative names
    • PK 26124
  • Biological descriptionNeuroprotective agent with anticonvulsant, sedative, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release, enhances glutamate uptake, blocks voltage-dependent Na+ channels, antagonises NMDA receptors and inhibits GABA uptake. Reported to offer neuroprotection and some therapeutic potential for amyotrophic lateral sclerosis and Huntingdon's disease.
  • Purity> 99%

Properties

    References for Riluzole (PK 26124) (ab120272)

    This product has been referenced in:
    • Fumagalli E  et al. Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur J Pharmacol 578:171-6 (2008). Read more (PubMed: 18036519) »
    • Lamanauskas N & Nistri A Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro. Eur J Neurosci 27:2501-14 (2008). Read more (PubMed: 18445055) »
    • Doble A The pharmacology and mechanism of action of riluzole. Neurology 47:S233-41 (1996). Read more (PubMed: 8959995) »

    See 1 Publication for this product

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