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Product name
Rottlerin
Description
Kinase inhibitor
Biological description
Originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (5.4 and 1.9 μM respectively), CHK2, PLK1, PIM3 and SRPK1.
Purity
> 95%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Molecular Weight
516.55
Chemical structure
Molecular formula
C30H28O8
CAS Number
82-08-6
Solubility
Soluble in DMSO to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Protein Kinase C >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> General >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Rottlerin (ab120377)
This product has been referenced in:
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
- Davies SP et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105 (2000).Read more (PubMed: 10998351) »
See all 3 publications for this product
Publishing research using ab120377? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"