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AbcamBiochemicals (Asc-410)

RuBi-4AP (ab120410)

Q&A (7)

Overview

  • Product nameRuBi-4AP
  • Description
    Caged K+ channel blocker, uncaged by visible light
  • Biological descriptionWater soluble caged 4-aminopyridine (4-AP) based on ruthenium photochemistry. Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases voltage-dependent K+ channel blocker 4-aminopyridine (ab120122) when uncaged.
  • General notes

    RuBi-4AP is light sensitive and it is recommended that the compound is protected from light.

    Sold under license from Columbia University; Patent Pending

    • Properties

  • Chemical nameBis(2,2'-bipyridine-N,N')bis(4-aminopyridine-N1) ruthenium(2+) dichloride complex
  • Molecular Weight672.58
  • Chemical structureChemical Structure
  • Molecular formulaC30H28Cl2N8Ru
  • Storage instructionsStore at -20°C (desiccating conditions).
  • Solubility overviewSoluble in water
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for RuBi-4AP (ab120410)

    This product has been referenced in:

    See 0 Publications for this product

    Publishing research using ab120410 ? Please let us know so that we can cite the reference in this datasheet

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    Submit a Question for ab120410

    Displaying 1 - 7 of 7 results for Q&A

    10
    Votes: Highest First

    Hello,
    I would like to order the remaining vials of RuBi-4AP from lot APN12359-1-1 at this time. The product is working very nicely. How can I best expedite this process?
    Thanks,

    I now have further information to share with you in regards to the RuBi-4AP (ab120410). We do not have any further stock of lot number APN12359-1-1 available other than the 7 vials you have placed an order for.
    We will however be producing more of th...

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    Hello,
    I would like to order the remaining vials of RuBi-4AP from lot APN12359-1-1 at this time. The product is working very nicely. How can I best expedite this process?
    Thanks,

    Thank you for your email.
    I am pleased to hear that you have found the RuBi-4AP (ab120410) to work well for you.
    We currently have a total of 7 vials of the lot number APN12359-1-1 in stock (7x10 mg). As you are ordering using a credit card you ...

    Read More

    Hi,
    After some initial testing on the new RuBi-4AP compound, it appears that this lot (#APN12359-1-1) is pure and working well. I thank you for your efforts in getting this
    material to a high standard. How many vials of this lot are now currentl...

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    Thank you for getting back to us with that information.
    I am glad to hear the new RuBi-4AP (ab120410) has worked well for you. We currently have a further 3 vials (3x10 mg) of the same lot, APN12359-1-1, in stock. We would expect to have further mate...

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    Hi,
    Please send the replacement vials(RuBi-4AP, ab120410) at your earliest convenience!
    Thanks,

    Thank you for that confirmation.
    I have arranged for a new order of 3 vials of RuBi-4AP to be sent to you (free of charge) as soon as we have it available. This is on the order number xxxxxx. If you have any questions regarding the status of the orde...

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    Thank you for your prompt action. 4-AP has a very potent effect on the channels we are studying, therefore even low levels of non-caged compound are strongly inhibited.
    I would prefer to wait for the replacement.
    Should I refer any queries about t...

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    Thank you for your patience and understanding in this matter.
    Once the new batch of RuBi-4AP is ready, I will send on 3 replacement vials to you. If you have any other questions or concerns in the meantime, please feel free to drop me an email.
    I ...

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    I have encountered a problem with the Rubi-4AP I ordered (*). This is a 'caged' compound.
    It appears that the compound is not well caged in this batch. Although the compound was never exposed to light,
    results with the caged Rubi-4AP are similar t...

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    Thank you for your patience in this matter/
    Following analysis we have some more information about this compound. It appears that low levels of 4-AP (about 6%) have been detected in the sample. We are in the process of improving the purity and would l...

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    I have encountered a problem with the Rubi-4AP I ordered (Batch *). This is a 'caged' compound.
    It appears that the compound is not well caged in this batch. Although the compound was never exposed to light,
    results with the caged Rubi-4AP are sim...

    Read More

    Thank you for contacting Abcam.
    I am sorry about the issues you are having with ab120410. We are currently looking into this issue and checking our current stock, so that we can be sure that what we have, is working as it should.
    Once I hear back ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"