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Products:Neuroscience >> Neurotransmission >> Calcium Signaling >> Calcium Channels >> Ryanodine Receptors
Anti-Ryanodine Receptor (phospho S2808) antibody (ab59225)
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Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Publishing research using ab59225? Please let us know so that we can cite the reference in this datasheet
ab59225 has been referenced in 2 publications.
- Barrientos GC et al. Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle. J Biol Chem 287:2863-76 (2012). WB; Mouse. PubMed: 22139840
- Feng W et al. Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice. Mol Pharmacol 79:420-31 (2011). WB; Mouse. PubMed: 21156754
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Immunohistochemistry (Paraffin-embedded sections) - Ryanodine Receptor (phospho S2808) antibody (ab59225)
ab59225 (1/50 dilution) staining Ryanodine Receptor in human brain tissue by Immunohistochemistry (Paraffin section); in the absence or presence of the immunizing peptide.
Western blot - Anti-Ryanodine Receptor (phospho S2808) antibody (ab59225)
Representative Western blot showing Ser(P)2844-RYR1 levels before and after treatment with PP1. The bottom panel summarizes the amount of specific [3H]Ry binding to muscle membranes isolated from WT, Het, and Hom T4826I mice with and without PP1 treatment. PP1 effectively dephosphorylates Ser(P)2844-RYR1 but has no effect on [3H]Ry binding levels, which remain significantly higher in preparations from Het and Hom mutants. ab59225 was used at a 1/2000 dilution.
Image from Barrientos GC et al, J Biol Chem. 2012 Jan 20;287(4):2863-76. Epub 2011 Dec 2, FIg 6. DOI 10.1074/jbc.M111.307926 January 20, 2012 The Journal of Biological Chemistry, 287, 2863-2876.
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