Overview

  • Product name
    (S)-CR8
  • Description
    Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor
  • Biological description
    Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor (IC50 = 41 - 400 nM). (R)-DRF053 (ab141505) analog. More potent than roscovirtine. Apoptosis inducer. GSK-3α/β (glycogen synthase kinase-3α/β) inhibitor. Antitumor potential.

    See similar compound
  • Purity
    > 98%

Properties

  • Chemical name
    (2S)-2-[[9-Propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol
  • Molecular weight
    431.53
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C24H29N7O
  • CAS Number
    1084893-56-0
  • PubChem identifier
    25211051
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Soluble in ethanol to 25 mM and in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC[C@@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=C(C=C3)C4=CC=CC=N4)N=CN2C(C)C
  • Source

    Synthetic

    References for (S)-CR8 (ab144231)

    This product has been referenced in:
    • Bukanov NO  et al. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle 11:4040-6 (2012). Read more (PubMed: 23032260) »
    • Besson A  et al. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159-69 (2008). Read more (PubMed: 18267085) »
    • Bettayeb K  et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene 27:5797-807 (2008). Read more (PubMed: 18574471) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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