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Product name
(S)-(+)-Rolipram
Description
PDE4 inhibitor; less active enantiomer
Biological description
PDE4 inhibitor (IC50 = 0.58 µM). Less active enantiomer.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Molecular Weight
275.35
Chemical structure
Molecular formula
C16H21NO3
CAS Number
85416-73-5
Solubility
Soluble in DMSO to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Phosphodiesterase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for (S)-(+)-Rolipram (ab120030)
This product has been referenced in:
- Souness JE & Scott LC Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase. Biochem J 291 ( Pt 2):389-95 (1993).Read more (PubMed: 8387267) »
- Schneider HH et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur J Pharmacol 127:105-15 (1986).Read more (PubMed: 3019721) »
See all 3 publications for this product
Publishing research using ab120030? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"